A common variant in BRCA2 is associated with both breast cancer risk and prenatal viability
β Scribed by Healey, Catherine S.; Dunning, Alison M.; Dawn Teare, M.; Chase, Diana; Parker, Louise; Burn, John; Chang-Claude, Jenny; Mannermaa, Arto; Kataja, Vesa; Huntsman, David G.; Pharoah, Paul D.P.; Luben, Robert N.; Easton, Douglas F.; Ponder, Bruce A.J.
- Book ID
- 109829443
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 86 KB
- Volume
- 26
- Category
- Article
- ISSN
- 1061-4036
- DOI
- 10.1038/81691
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Genetic screening of women from multiple-case breast cancer families and other research-based endeavors have identified an extensive collection of germline variations of BRCA1 and BRCA2 that can be classified as deleterious and have clinical relevance. For some variants, such as those in the conserv
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