A common topology for bacterial and eukaryotic transcription initiation?
β Scribed by Travers, Andrew; Muskhelishvili, Georgi
- Book ID
- 110033244
- Publisher
- Nature Publishing Group
- Year
- 2007
- Tongue
- English
- Weight
- 219 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1469-221X
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Two simpli"ed kinetic proofreading scanning (KPS) models were proposed to describe the 5 cap and 3 poly(A) tail dependency of eukaryotic translation initiation. In Model I, the initiation factor complex starts scanning and unwinding the secondary structure of the 5 untranslated region (UTR) from the
## Abstract Eukaryotic translation initiation factor 5A (eIF5A) has a unique character: the presence of an unusual amino acid, hypusine, which is formed by postβtranslational modifications. Even before the identification of hypusination in eIF5A, the correlation between hypusine formation and prote