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A common polymorphism in the brain-derived neurotrophic factor gene in patients with adult-onset primary focal and segmental dystonia

✍ Scribed by Marina V. Svetel, Gordana Djuric, Ivana Novakovic…

Book ID: 120738353
Publisher: Royal Association of Belgian Medical Scientific Societies
Year: 2013
Tongue: English
Weight: 167 KB
Volume: 113
Category: Article
ISSN: 0300-9009
DOI: 10.1007/s13760-013-0183-9

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## Abstract Several lines of evidence indicate an involvement of brain derived neurotrophic factor (BDNF) in body weight regulation and activity: heterozygous __Bdnf__ knockout mice (__Bdnf__^+/−^) are hyperphagic, obese, and hyperactive; furthermore, central infusion of BDNF leads to severe, dose‐