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A common human TLR1 polymorphism regulates the innate immune response to lipopeptides

✍ Scribed by Thomas R. Hawn; E. Ann Misch; Sarah J. Dunstan; Guy E. Thwaites; Nguyen T. N. Lan; Hoang T. Quy; Tran T. H. Chau; Stephanie Rodrigues; Alex Nachman; Marta Janer; Tran T. Hien; Jeremy J. Farrar; Alan Aderem


Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
241 KB
Volume
37
Category
Article
ISSN
0014-2980

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Toll-like receptors (TLR) have a key role in regulating immunity against microbial agents. Engagement of TLR by bacterial, viral or fungal components leads to the production and release of inflammatory cytokines. In this study we show that mainly TLR8 and also TLR7 act as the host sensors for human