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A common evolutionary origin for class I molecules of the MHC and T1 a region

✍ Scribed by T.J. Kindt


Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
205 KB
Volume
2
Category
Article
ISSN
0167-5699

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A major role for tapasin as a stabilizer
✍ Natalio Garbi; Neeraj Tiwari; Frank Momburg; GΓΌnter J. HΓ€mmerling πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 305 KB

Tapasin is a member of the MHC class I loading complex where it bridges the TAP peptide transporter to class I molecules. The main role of tapasin is assumed to be the facilitation of peptide loading and optimization of the peptide cargo. Here, we describe another important function for tapasin. In