A COMMON DNA POLYMORPHISM OF THE LOW-DENSITY LIPOPROTEIN (LDL) RECEPTOR GENE AND ITS USE IN DIAGNOSIS
β Scribed by Humphries, S.E.; Horsthemke, B.; Seed, M.; Holm, M.; Wynn, V.; Kessling, A.M.; Donald, J.A.; Jowett, N.; Galton, D.J.; Williamson, R.
- Book ID
- 123295487
- Publisher
- The Lancet
- Year
- 1985
- Tongue
- English
- Weight
- 525 KB
- Volume
- 325
- Category
- Article
- ISSN
- 0140-6736
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DNA sequencing of enzymatically-amplified exons of the low-density lipoprotein receptor gene from several individuals revealed a polymorphism in exon 10 of the gene. The codon for arginine 450 was converted from AGG to AGA in some alleles.