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A Common Binding Site for Channel-Permeant Cations and Local Anesthetics on the Nicotinic Acetylcholine Receptor

✍ Scribed by JEFFREY M. HERZ; STEPHEN KOLB; THOMAS ERLINGER


Book ID
119866296
Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
193 KB
Volume
625
Category
Article
ISSN
0890-6564

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## Abstract Reaction of glutarimide with pent‐4‐enylmagnesium bromide, followed by cyclization of intermediate ketoamide, and hydrolysis of the formates **10** and **13** led to the mixture of the hydroxylactams **11** __(cis)__ and **14** __(trans)__ which could be separated __via__ their benzenec