✦ LIBER ✦
A Combinatorial Approach to Heterogeneous Asymmetric Aquacatalysis with Amphiphilic Polymer-Supported Chiral Phosphine-Palladium Complexes
✍ Scribed by Yukinari Kobayashi; Daiki Tanaka; Hiroshi Danjo; Yasuhiro Uozumi
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 726 KB
- Volume
- 348
- Category
- Article
- ISSN
- 1615-4150
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✦ Synopsis
Abstract
A library of amphiphlic polystyrene‐poly(ethylene glycol) (PS‐PEG) resin‐supported chiral phosphine ligands was prepared by the split method using porous miniature reactors. A polymeric (R)‐2‐(diphenylphosphino)binaphthyl (MOP) ligand anchored onto the PS‐PEG resin by an (S)‐alanine tether unit was identified through the library‐based screening to be an effective chiral ligand for the asymmetric palladium‐catalyzed π‐allylic substitution under heterogeneous aqueous conditions.