Genetic alterations in sporadic renal-ce
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H. Brauch; S. Pomer; T. Hieronymus; T. Schadt; H. LΓΆhrke; D. Komitowski
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Article
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1994
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Springer-Verlag
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English
β 935 KB
On a genetic level, renal-cell carcinoma has been characterized by an abnormality on the short arm of chromosome 3 (3p), which suggests the inactivation of a tumor suppressor gene. One tumor suppressor gene at 3p, the von Hippel-Lindau disease gene, is implicated in tumor development of a whole spec