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A combination of molecular cytogenetic analyses reveals complex genetic alterations in conventional renal cell carcinoma

✍ Scribed by Jon C. Strefford; Irina Stasevich; Tim M. Lane; Yong-Jie Lu; Tim Oliver; Bryan D. Young


Book ID
113512600
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
695 KB
Volume
159
Category
Article
ISSN
0165-4608

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On a genetic level, renal-cell carcinoma has been characterized by an abnormality on the short arm of chromosome 3 (3p), which suggests the inactivation of a tumor suppressor gene. One tumor suppressor gene at 3p, the von Hippel-Lindau disease gene, is implicated in tumor development of a whole spec