A cold precipitable fibrinogen complex in the plasma of cattle dying from infection withBabesia argentina
✍ Scribed by B. V. Goodger
- Book ID
- 104751603
- Publisher
- Springer-Verlag
- Year
- 1975
- Tongue
- English
- Weight
- 505 KB
- Volume
- 48
- Category
- Article
- ISSN
- 1432-1955
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✦ Synopsis
Plasma from eattle dying from infection with Babesia argentina formed a eold precipitable gel when stored at 4 ° C. Immunodiftusion and electrophoresis showed the soluble phase of the gel to consist mainly of a fibrinogen-like protein with smM1 amounts of other plasma proteins. Gel filtration and specific clotting assays demonstrated a wide molecular weight spectrum of fibrinogen-like proteins, most of whieh appeared to be soluble fibrin in either monomer or complex forms. The possibility that proteolytic enzymes might be responsible for the formation of the gel is discussed.
It has been frequently observed at this laboratory that plasma from cattle dying from infeetion with the intraerythroeytie parasite Babesia argentina forms first a floceulent precipitate and then a gel when stored at 4°C for 2 to 3 hours. This paper describes the initial purifieation and identifieation of the plasma proteins coneerned with the gel formation and possible causes for the phenomenon are diseussed.