## Abstract __Introduction__. More than half of all drugs used in medical practice are metabolized by cytochrome CYP3A. Coadministration of drugs that share this elimination pathway may lead to pharmacokinetic drug interactions. Efforts are underway by clinical, drug development and regulatory scie
✦ LIBER ✦
A clinical evaluation of the Janus Web Application, a software screening tool for drug-drug interactions
✍ Scribed by Buster Mannheimer; Johanna Ulfvarson; Sara Eklöf; Monica Bergqvist; Christer von Bahr
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 107 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0031-6970
No coin nor oath required. For personal study only.
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P-glycoprotein (P-gp) is a multidrug transporter responsible for resistance to anticancer chemotherapy and physiologically involved in absorption, distribution, and excretion of a large number of hydrophobic xenobiotics. P-gp exhibits both an ATPase activity correlated with its drug transport functi