The application of a two-stage design fo
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Eisenberger, Mario A. ;Ellenberg, Susan ;Leyland-Jones, Brian ;Friedman, Michael
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Article
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1988
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John Wiley and Sons
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English
β 620 KB
Cytotoxic chemotherapy produces modest benefits for patients with recurrent and metastatic squamous cell carcinoma of the head and neck (SCCHN). Prospective randomized clinical trials have failed to demonstrate unequivocal superiority of aggressive multidrug regimens over single agents. Despite this