✦ LIBER ✦

A Class of 2,4-Bisanilinopyrimidine Aurora A Inhibitors with Unusually High Selectivity against Aurora B †

✍ Scribed by Aliagas-Martin, Ignacio; Burdick, Dan; Corson, Laura; Dotson, Jennafer; Drummond, Jason; Fields, Carter; Huang, Oscar W.; Hunsaker, Thomas; Kleinheinz, Tracy; Krueger, Elaine; Liang, Jun; Moffat, John; Phillips, Gail; Pulk, Rebecca; Rawson, Thomas E.; Ultsch, Mark; Walker, Leslie; Wiesmann, Christian; Zhang, Birong; Zhu, Bing-Yan; Cochran, Andrea G.

Book ID: 125495239
Publisher: American Chemical Society
Year: 2009
Tongue: English
Weight: 622 KB
Volume: 52
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm9000314

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Thieno[3,2-c]pyrazoles: A novel class of

Thieno[3,2-c]pyrazoles: A novel class of Aurora inhibitors with favorable antitumor activity

✍ Simona Bindi; Daniele Fancelli; Cristina Alli; Daniela Berta; Jay A. Bertrand; A 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 856 KB

Discovery, Synthesis, and in Vivo Activi

Discovery, Synthesis, and in Vivo Activity of a New Class of Pyrazoloquinazolines as Selective Inhibitors of Aurora B Kinase

✍ Mortlock, Andrew A.; Foote, Kevin M.; Heron, Nicola M.; Jung, Frédéric H.; Pasqu 📂 Article 📅 2007 🏛 American Chemical Society 🌐 English ⚖ 182 KB

Phase I study of barasertib (AZD1152), a

Phase I study of barasertib (AZD1152), a selective inhibitor of Aurora B kinase, in patients with advanced solid tumors

✍ Gary K. Schwartz,Richard D. Carvajal,Rachel Midgley… 📂 Article 📅 2012 🏛 Springer US 🌐 English ⚖ 389 KB

469 POSTER Detection of surrogate marker

469 POSTER Detection of surrogate markers of apoptosis in the peripheral blood of a preclinical tumour model treated with a selective inhibitor of Aurora B kinase (AZD1152)

✍ R.W. Wilkinson; R. Odedra; S.P. Heaton; C. Crafter; J. Growcott; K. Mundt; J. Cu 📂 Article 📅 2006 🏛 Elsevier Science 🌐 English ⚖ 60 KB

254 In Vitro and in Vivo Antitumor Activ

254 In Vitro and in Vivo Antitumor Activity of the Investigational Aurora A Selective Kinase Inhibitor MLN8237 Alone and in Combination with Standard Agents Against CRC Models

✍ Pitts, T.M.; McPhillips, K.L.; Selby, H.M.; Spreafico, A.; Bagby, S.M.; Britt, B 📂 Article 📅 2012 🏛 Elsevier Science 🌐 English ⚖ 61 KB

Design, synthesis and bioevaluation of d

Design, synthesis and bioevaluation of dihydropyrazolo[3,4-b]pyridine and benzo[4,5]imidazo[1,2-a]pyrimidine compounds as dual KSP and Aurora-A kinase inhibitors for anti-cancer agents

✍ Rong-geng Fu; Qi-dong You; Lei Yang; Wu-tong Wu; Cheng Jiang; Xiao-li Xu 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 633 KB