A chronic granuloma in brain amygdala modifies the pattern of contralateral kindled seizures
✍ Scribed by Minerva Calvillo; Carlos Paz; Julio Sotelo
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 457 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0893-6609
No coin nor oath required. For personal study only.
✦ Synopsis
Brain granulomas are among the most frequent causes of symptomatic epilepsy. We studied the dynamics of seizures induced by amygdala kindling in cats in whom a granuloma was induced one year before by injection of silicates in the contralateral amygdala. A paradoxical result was obtained; when compared to controls, the development of kindling in animals with granuloma had a Significant delay in the appearance of the first tonic-clonic seizure @<0.01) but a significant Prolongation of the duration of the afterdischarge @<0.01). These findings indicate that a granuloma located in an epileptogenic site can initially delay the appearance of seizures started in the homotopic contralateral area; but, once the seizures are elicited, they become more intense.