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A Chromosome-based method to infer IBD scores for missing and ambiguous markers

✍ Scribed by Dr. Chi Gu; Brian K. Suarez; Theodore Reich; Alexandre A. Todorov

Book ID: 102221624
Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 316 KB
Volume: 12
Category: Article
ISSN: 0741-0395
DOI: 10.1002/gepi.1370120657

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

We propose a probability model to impute missing identical‐by‐descent (IBD) vectors for linkage analysis, when adjacent marker loci are typed and interference is estimable. A chromosome‐based IBD distribution, conditioned on available marker data, is computed using a fast algorithm to estimate the joint probability of genes IBD at several equally spaced linked loci. Weighted IBD vectors are then used in various test statistics for linkage analysis. As an example, we analyzed the 18 affected sib pairs in the GAW9 Problem 1 data set using Risch's lod‐score test. © 1995 Wiley‐Liss, Inc.

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