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A chromosome 19 clone from a translocation breakpoint shows close linkage and linkage disequilibrium with myotonic dystrophy

โœ Scribed by Korneluk, R.G.; MacLeod, H.L.; McKeithan, T.W.; Brooks, J.D.; MacKenzie, A.E.

Book ID
122524729
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
996 KB
Volume
4
Category
Article
ISSN
0888-7543

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Myotonic dystrophy is associated with disturbances in the insulin response, possibly due to an abnormality of the insulin receptor. Both the myotonic dystrophy (DM) and insulin receptor (INSR) genes are on chromosome 19. Using a cloned gene probe for INSR, we have studied its linkage relationships w