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A CHO cell line engineered to express XBP1 and ERO1-Lα has increased levels of transient protein expression

✍ Scribed by Cain, Katharine; Peters, Shirley; Hailu, Hanna; Sweeney, Bernie; Stephens, Paul; Heads, James; Sarkar, Kaushik; Ventom, Andy; Page, Catherine; Dickson, Alan

Book ID
120491298
Publisher
American Institute of Chemical Engineers
Year
2013
Tongue
English
Weight
585 KB
Volume
29
Category
Article
ISSN
8756-7938

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A CHO cell line engineered to express XBP1 and ERO1-Lα has increased levels of transient protein expression
✍ Cain, Katharine; Peters, Shirley; Hailu, Hanna; Sweeney, Bernie; Stephens, Paul; 📂 Article 📅 2013 🏛 American Institute of Chemical Engineers 🌐 English ⚖ 585 KB

Transient gene expression (TGE) systems currently provide rapid and scalable (up to 100 L) methods for generating multigram quantities of recombinant heterologous proteins. Product titers of up to 1 g/L have been demonstrated in HEK293 cells but reported yields from Chinese hamster ovary (CHO) cell