A childhood fibrolamellar hepatocellular carcinoma with increased aromatase activity and a near triploid karyotype
✍ Scribed by Hany, Manuela A.; Betts, David R.; Schmugge, Markus; Schönle, Eugen; Niggli, Felix K.; Zachmann, Milo; Plüss, Hans-Jürg
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 87 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0098-1532
No coin nor oath required. For personal study only.
✦ Synopsis
We report a 15-year-old boy with hepatocel-had been present for at least 3 years prior to lular carcinoma (HCC) of the fibrolamellar type. diagnosis. At diagnosis the patient had multiple He presented with advanced disease and a non-metastases which included infiltrated ascites. resectable tumor. Clinical features included Cytogenetic analysis of the ascites revealed a marked gynecomastia which had been present near triploid karyotype with cell-to-cell variafor 3 years, failure to enter puberty, and failure tion and an abnormality of chromosome 1q. This to thrive. These features might have been due to our knowledge is the first karyotype report to a high aromatase activity of the tumor. The of fibrolamellar HCC in a child. Med. Pediatr. course of the illness suggested that the tumor