A chemical Investigation of Celastrus Paniculata Willd.*

✍ Scribed by Basu, N.K. ;Pabrai, P.R.

• Publisher: Elsevier
• Year: 1946
• Weight: 200 KB
• Volume: 35
• Category: Article
• ISSN: 0095-9553
• DOI: 10.1002/jps.3030350906

✦ Synopsis

c) Dilatation of coronary and other circulatory vessels as shown on the turtle and rabbit. (d) Dilatation of bronchiolar vessels as shown on the lungs of the guinea (e) Low toxicity when given by mouth or intravenously to rats. (f) Stability in gastric and intestinal fluids, a characteristic not possessed by theophylline derivatives now in use.

Pig.

Dihydroxypropyl theophylline, being a definite chemical compound, is probably absorbed unchanged for the exertion of its pharmacological action, an event which provides definite advantages for clinical studies not present with theophylline derivatives now in use.

Most theophylline derivatives now in use apparently decompose, leaving basic theophylline in digestive fluids to perform

5 .

its pharmacological and therapeutic effect. REFERENCES (1) "Council on Pharmacy and Chemistry," J . A m . Med. Assac.. 94, 17, 1306(1930).

(2) Amep, G. V., Arch. cxpfl. Palh. Pharmakol., 138, 118 i i a 3 ~)

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(3) Heathcote. R. St. A,.