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A Chemical, Genetic, and Structural Analysis of the Nuclear Bile Acid Receptor FXR

โœ Scribed by Michael Downes; Mark A. Verdecia; A.J. Roecker; Robert Hughes; John B. Hogenesch; Heidi R. Kast-Woelbern; Marianne E. Bowman; Jean-Luc Ferrer; Andrew M. Anisfeld; Peter A. Edwards; John M. Rosenfeld; Jacqueline G.A. Alvarez; Joseph P. Noel; K.C Nicolaou; Ronald M. Evans


Book ID
117737082
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
973 KB
Volume
11
Category
Article
ISSN
1097-2765

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The nuclear bile acid receptor FXR as a
โœ Michael Trauner ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 216 KB ๐Ÿ‘ 2 views

Farnesoid X receptor (FXR) is a bile acid-activated transcription factor that is a member of the nuclear hormone receptor superfamily. FXR-null mice exhibit a phenotype similar to Byler disease, an inherited cholestatic liver disorder. In the liver, activation of FXR induces transcription of transpo