Melanocyte cultures from the normally pigmented skin of patients with neurofibromatosis 1 (NF 1) have a higher melanin content than those from the skin of healthy donors. An additional increase in the amount of melanin per cell was found in 5 out of 6 lines of melanocytes derived from caf6 au lait m
A cell culture study on melanocytes from patients with neurofibromatosis-1
β Scribed by D. Kaufmann; W. Krone; R. Hochsattel; R. Martin
- Book ID
- 104789707
- Publisher
- Springer-Verlag
- Year
- 1989
- Tongue
- English
- Weight
- 329 KB
- Volume
- 281
- Category
- Article
- ISSN
- 0340-3696
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π SIMILAR VOLUMES
Neurofibromatosis type 1 (NF1) is characterized by clinical features that primarily affect tissues derived from the neural crest (neurofibromas, caf~-aulait macules). Because aberrant regulation of alternative splicing in the NF1 gene transcript may be of functional significance, cultured melanocyte
4 from patients with Von Hippel-Lindau syndrome (m). The diagnosis was confirmed in each NF1 patient and conformed to internationally agreed criteria (Riccardi and Eichner, 1986;Mulvihill and Parry, 1987). The diagnosis of MEN 2 and VHL was similarly con-
## Abstract Neurofibromatosis 1 (NF1) is associated with many internal complications as well as skin manifestations, and patients may require a variety of medical and surgical interventions. We aimed to assess the medical needs of NF1 patients, and to evaluate the financial cost of the resources us