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A cell-based high-throughput screen to identify synergistic TRAIL sensitizers

✍ Scribed by Nancy Lynn Booth; Thomas J. Sayers; Alan D. Brooks; Cheryl L. Thomas; Kristen Jacobsen; Ekaterina I. Goncharova; James B. McMahon; Curtis J. Henrich


Publisher
Springer-Verlag
Year
2008
Tongue
English
Weight
518 KB
Volume
58
Category
Article
ISSN
0340-7004

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Increasing numbers of target protein structures available for computational studies makes the structure-based screening paradigm more attractive for initial hit indentification. We have developed a novel in silico screening methodology incorporating Molecular Mechanics (MM)/implicit solvent methods