A cell-autonomous requirement for the cell cycle regulatory protein, Rb, in neuronal migration
โ Scribed by Ferguson, Kerry L; McClellan, Kelly A; Vanderluit, Jacqueline L; McIntosh, William C; Schuurmans, Carol; Polleux, Franck; Slack, Ruth S
- Book ID
- 110031276
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 464 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0261-4189
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract The serine/threonine kinase PAK4 regulates cytoskeletal architecture, and controls cell proliferation and survival. In most adult tissues PAK4 is expressed at low levels, but overexpression of PAK4 is associated with uncontrolled proliferation, inappropriate cell survival, and oncogenic
RB family members are post-transductionally regulated proteins and phosphorylation at Ser/Thr residues leads to their gradual inactivation. Cyclin/cdk complexes are mainly responsible for the regulation of these pocket proteins, which is crucial for release of E2F factor. Despite the fact that E2F r