A cDNA clone representative of a novel splicing pattern of theD. melanogaster duncegene

✍ Scribed by M. Furia; E. Giordano; A. Digilio; L. C. Polito

• Book ID: 104678540
• Publisher: Springer Netherlands
• Year: 1993
• Tongue: English
• Weight: 410 KB
• Volume: 87
• Category: Article
• ISSN: 0016-6707
• DOI: 10.1007/bf00240555

✦ Synopsis

The D. melanogaster dunce gene is involved in both the learning and memory processes of the fly. The gene encodes for a cAMP-specific phosphodiesterase, a function playing a central role in the regulation of the intracellular cAMP level. Molecular cloning of dunce has so far not been completely achieved, although it is known that the gene encodes a large set of RNAs and has a complex organization, extending for more than 140 kilobases and containing several genes within its introns. Here we report the isolation and the characterization of 21/7, a cDNA clone representative of a novel dunce splicing pattern. The nucleotide sequence of this clone led to the identification of a dunce exon included in at least one transcript so far uncharacterized.