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A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity

โœ Scribed by Montagnoli, Alessia; Valsasina, Barbara; Croci, Valter; Menichincheri, Maria; Rainoldi, Sonia; Marchesi, Vanessa; Tibolla, Marcello; Tenca, Pierluigi; Brotherton, Deborah; Albanese, Clara

Book ID
109913542
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
447 KB
Volume
4
Category
Article
ISSN
1552-4450

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โœ Hisao Masai; Ken-Ichi Arai ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 248 KB ๐Ÿ‘ 1 views

## Abstract DNA replication results from the action of a staged set of highly regulated processes. Among the stages of DNA replication, initiation is the key point at which all the G1 regulatory signals culminate. Cdc7 kinase is the critical regulator for the ultimate firing of the origins of initi