Induction and maintenance of peripheral tolerance are important mechanisms to maintain the balance of the immune system. In addition to the deletion of T cells and their failure to respond in certain circumstances, active suppression mediated by T cells or T-cell factors has been proposed as a mecha
A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
✍ Scribed by Roncarolo, Maria Grazia; Groux, Hervé; O'Garra, Anne; Bigler, Mike; Rouleau, Matthieu; Antonenko, Svetlana; de Vries, Jan E.
- Book ID
- 109800059
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 930 KB
- Volume
- 389
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/39614
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## Abstract Naturally occurring CD4^+^ regulatory T cells can be identified on the basis of expression of CD25 and suppression of T cell responses __in vitro__ after TCR triggering. Here, we demonstrate that a CD134^+^ subset of CD4^+^CD25^+^ T cells in naive rats suppresses antigen‐specific T cell