A CD44 variant exon 6 epitope as a prognostic indicator in breast cancer
β Scribed by Udo Schumacher; Hans-Peter Horny; Heinz-August Horst; Peter Herrlich; Edwin Kaiserling
- Book ID
- 117569364
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 252 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0748-7983
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Breast cancer is the most common female malignancy affecting approximately one woman in eight. Many attempts have been made to define markers which may have potential clinical applications in diagnosis as well as therapy. New isoforms of CD44 with alternative spliced exons have recently been describ
CD44 is a family of cell surface transmembrane glycoproteins members which differ in the extracellular part by sequences derived by alternative splicing of 10 variant exons (v1-v10). CD44 proteins containing such variant sequences have been implicated in tumor metastasis formation. Here, we have eva