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A CD40 Signalosome Anchored in Lipid Rafts Leads to Constitutive Activation of NF-κB and Autonomous Cell Growth in B Cell Lymphomas

✍ Scribed by Lan V Pham; Archito T Tamayo; Linda C Yoshimura; Piao Lo; Nicholas Terry; Pamela S Reid; Richard J Ford


Book ID
117723165
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
918 KB
Volume
16
Category
Article
ISSN
1074-7613

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## Abstract The transcription factor nuclear factor‐κB (NF‐κB) has been shown to be constitutively activated in various human malignancies, including leukemia, lymphoma and a number of solid tumors. NF‐κB regulates the transcriptional of genes important for tumor invasion, metastasis and chemoresis