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A catalytic site of protein disulfide isomerase probed with adenosine-5′-triphosphate analogs

✍ Scribed by Jorge E Churchich; K.S Lee


Book ID
114148698
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
311 KB
Volume
1479
Category
Article
ISSN
0167-4838

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We have synthesized 2'-deoxy-2'-iodoadenosine-5'-triphosphate (2'-IATP), a heavy-atom analog of adenosine-5'-triphosphate. This compound was made for X-ray structural studies to target the nucleotide site of ATP binding proteins. It was diffused successfully into crystals of the microtubule-based mo