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A case study of combinatorial libraries: Endothelin receptor antagonist hexapeptides

✍ Scribed by B. Neustadt; A. Wu; E.M. Smith; T. Nechuta; A. Fawzi; H. Zhang; A.K. Ganguly

Book ID
108038883
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
235 KB
Volume
5
Category
Article
ISSN
0960-894X

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A combinatorial library of 30,752 compounds has been synthesised from a set of 32 natural and unnatural amino acids. The library was designed to include the known endothelin antagonist, FR-139,317, as a positive control, and this and a number of close analogues were shown to be the most potent compo