A case of gastric carcinoma associated with excessive granulocytosis. Production of a colony-stimulating factor by the tumor

✍ Scribed by Takao Obara; Yukio Ito; Takaya Kodama; Yoshihide Fujimoto; Hideaki Mizoguchi; Kazuo Oshimi; Masatomo Takahashi; Akira Hirayama

• Publisher: John Wiley and Sons
• Year: 1985
• Tongue: English
• Weight: 1013 KB
• Volume: 56
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(19850815)56:4<782::aid-cncr2820560414>3.0.co;2-5

✦ Synopsis

A patient with gastric carcinoma exhibited an excessive granulocytosis (58,000/pl) preoperatively, in the absence of overt infection. After resection of the primary tumor, the peripheral leukocyte count decreased promptly to the normal value. In a search for a colony-stimulating factor (CSF), the tumor was transplanted into nude mice. A marked neutrophilia was observed in the tumor-bearing mice, suggesting the production of CSF by the tumor. Media conditioned by the primary culture of the tumor cells revealed the presence of CSF activity as well. CSF-producing carcinomas have been detected in various organs; nevertheless, no cases of gastric carcinoma have hitherto been described. It is of particular interest that in this patient hypercalcemia was not observed, although it often accompanied CSF-producing tumors reported previously. Therefore, it is suggested that this tumor secreted pure CSF and that the CSF produced by the tumor did not necessarily induce hypercalcemia.