A case of fatal overwhelming microgranular variant (M3v) of acute promyelocytic leukemia with extensive extramedullary involvement
β Scribed by Claudio Romani; R. Murru; M. Pettinau; A. A. Di Tucci; F. Culurgioni; D. Pulisci; E. Angelucci
- Book ID
- 107618993
- Publisher
- Carden Jennings Publishing
- Year
- 2010
- Tongue
- English
- Weight
- 154 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0925-5710
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## BACKGROUND. Extramedullary involvement is only occasionally observed in patients with acute promyelocytic leukemia (APL) but has been said to occur more frequently after treatment with all-trans retinoic acid (ATRA) than after treatment with cytotoxic drugs. In the literature, 37 well-documented
Acute promyelocytic leukemia (APL) is characterized by the presence of a chromosomal rearrangement involving retinoic acid receptor alpha (RARalpha) gene generating the X-RARalpha fusion. We describe here a unique RARalpha gene rearrangement in a patient with M3r subtype of APL. Conventional cytogen