A case of familial thyroxine binding globulin excess associated with growth hormone deficiency
โ Scribed by AKIO NAKAI; YOSUKE SHIGEMATSU; YOSHIHARU KIKAWA; MASAKATSU SUDO
- Book ID
- 118712026
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 282 KB
- Volume
- 36
- Category
- Article
- ISSN
- 1328-8067
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๐ SIMILAR VOLUMES
Idiopathic growth hormone deficiency is, in most cases, a sporadic condition. In a number of these patients magnetic resonance imaging (MRI) demonstrates a small anterior pituitary, small or absent pituitary stalk, and ectopically located posterior pituitary. These findings have been attributed to a
The variant thyroxine-binding globulin in a family from Montreal (TBG-M) has a reduced affinity for thyroxine, shows a slight cathodal shift on isoelectric focusing, and has an increased susceptibility to inactivation by heat and acid. We present the molecular basis for TBG-M, deduced by sequencing