A case-control study of cutaneous squamous cell carcinoma among Caucasian organ transplant recipients: The role of antibodies against human papillomavirus and other risk factors
✍ Scribed by Delphine Casabonne; Aoife Lally; Liza Mitchell; Kristina M. Michael; Tim Waterboer; Michael Pawlita; Beata Imko-Walczuk; Fenella Wojnarowska; Charlotte Proby; Catherine Harwood; Robert Newton
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- French
- Weight
- 436 KB
- Volume
- 125
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Abstract
A case‐control study was conducted in 140 people with histology proven cutaneous squamous cell carcinoma (SCC) and 454 controls, nested within 2 cohorts of organ transplant recipients (OTR) recruited in London and Oxford between 2002 and 2006. All participants had a skin examination, completed a questionnaire and had serum tested for antibodies against the L1 antigen of 34 HPV types using Luminex technology. SCC was more common in men than women (odds ratio [OR] = 1.7, 95% confidence interval [CI]: 1.1–2.8, p = 0.02) and in people with susceptibility to burn easily (OR = 3.0, 95%CI: 1.9–4.8; p < 0.001). The risk increased with increasing age (p‐trend < 0.001), increasing time since transplant (p‐trend < 0.001), increasing self‐reported number of sunburns as a child (p‐trend < 0.001) and with the presence of viral warts (p < 0.001). As expected, antibodies against HPV 16 were associated with a self‐reported history of an abnormal cervical smear among women (OR 5.1, 95%CI: 2.6–10.2) and antibodies against HPV 6 were associated with a self‐reported history of genital warts (OR 4.0, 95%CI: 2.2–7.2). However, no clear associations between any of the HPV types examined (including cutaneous betaHPVs) and SCC were identified. For example, the seroprevalence of HPV 5 was 15% among cases and 9% among controls (p = 0.09) and the seroprevalence of HPV 8 was 23% among cases and 21% among controls (p = 0.6). Nor was seropositivity to multiple types associated with SCC. These serological data do not provide evidence for a role for HPV in the aetiology of cutaneous SCC among OTR in two UK‐based populations. © 2009 UICC