A ‘carrier effect’ observed in assays for antidiarrhoeal drug compounds

✍ Scribed by N. J. Haskins; G. C. Ford; S. J. W. Grigson; K. A. Waddell

• Publisher: John Wiley and Sons
• Year: 1978
• Tongue: English
• Weight: 168 KB
• Volume: 5
• Category: Article
• ISSN: 1076-5174
• DOI: 10.1002/bms.1200050610

✦ Synopsis

A carrier effect has been shown to exist in a stable isotope dilution assay for diphenoxylate. When a tetradeuterated analogue is used as a carrier and internal standard a sevenfold increase in sensitivity is observed for the unlabelled compound. Examination of a related pharmacologically active compound (SC-27166) showed a much smaller effect.