✦ LIBER ✦
A carcinoembryonic antigen (CEA) specific monoclonal hybridoma antibody that reacts only with high-molecular-weight CEA
✍ Scribed by Kenneth F. Mitchell
- Publisher
- Springer-Verlag
- Year
- 1980
- Tongue
- English
- Weight
- 714 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0340-7004
No coin nor oath required. For personal study only.
✦ Synopsis
A monoclonal antibody secreted by a hybridoma, formed by the fusion of a spleen cell from an immunized mouse and a mryeloma cell, has been shown to react only with a form of carcinoembryonic antigen (CEA) with a molecular weight of 180,000 daltons. The monoclonal antibody precipitates a 180,000-dalton form of CEA from colorectal carcinoma cell lysates, purified iodinated CEA and iodinated CEA-S, but does not precipitate the 'cross-reactive' antigen (NCA) from normal colon.