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A carbon-13 magnetic resonance study of the helix–coil transition in polyuridylic acid

✍ Scribed by Girjesh Govil; Ian C. P. Smith

Publisher
Wiley (John Wiley & Sons)
Year
1973
Tongue
English
Weight
545 KB
Volume
12
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

The temperature‐dependent conformations of poly(U) in 0.5__M__ CsC1 have been studied by carbon‐13 nuclear magnetic resonance. The transition from random coil to an ordered structure results in broadening of lines in the ^13^C spectra, due to intramolecular ^1^H–^13^C dipolar interactions and restricted motions in the ordered state. Changes in the chemical shifts suggest that the bases are interacting below the transition temperature. The random coil form shows conformation preferences for internal rotation about C4′–C5′, C5′–O5′, and C3′–O 3′ bonds. The statistical randomness of the coil arises mainly because of flexibility about O–P bonds. The results are analyzed in conjunction with theoretical calculations and light‐scattering data.

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