✦ LIBER ✦
A calculator program for least-squares parameter estimation according to the one-compartment kinetic model with zero-order input
✍ Scribed by Andrea Messori; Giancarlo Donati-Cori; Enrico Tendi
- Publisher
- Elsevier Science
- Year
- 1984
- Weight
- 382 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0010-468X
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✦ Synopsis
A calculator program that performs a nonlinear least-squares fit to data conforming to the one-compartment model with zero-order input is described. The program, which is designed for the Hewlett-Packard HP-41 CV calculator, is based on the Gauss-Newton iterative algorithm as modified by Hartley. A subroutine for calculation of initial parameter estimates is incorporated into the program. Plasma concentration data relative to a single oral dose of a sustained-release theophylline formulation are used to demonstrate the practical application of the program.