✦ LIBER ✦

A brute force dichotomization approach to quantitative trait linkage analysis

✍ Scribed by Julia N. Bailey; Laura Almasy

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 247 KB
Volume: 12
Category: Article
ISSN: 0741-0395
DOI: 10.1002/gepi.1370120631

No coin nor oath required. For personal study only.

✦ Synopsis

The effect of dichotomizing a continuous phenotype in linkage analysis of a simulated oligogenic trait is explored. We conclude that dichotomization does not in itself preclude the detection of loci which account for as little as 16% of the genetic variance of the disease. The effects of inclusion of known covariates and quantitative trait linkage analysis are also discussed. 1995 Wiley-Liss, Inc.

📜 SIMILAR VOLUMES

A variance component approach to dichoto

A variance component approach to dichotomous trait linkage analysis using a threshold model

✍ Ravindranath Duggirala; Jeff T. Williams; Sarah Williams-Blangero; John Blangero 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 65 KB 👁 2 views

We developed and utilized a multipoint variance components method to test for linkage between a disease trait and markers on chromosome 5 in the simulated data provided in GAW10 Problem 2. We demonstrated that the discrete trait variance components method recovers unbiased estimates of quantitative

Joint segregation and linkage analysis o

Joint segregation and linkage analysis of a quantitative trait compared to separate analyses

✍ W. James Gauderman; Cheryl L. Faucett; John L. Morrison; Catherine L. Carpenter 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 36 KB 👁 2 views

Our goal was to determine the degree to which joint segregation and linkage analysis leads to increased efficiency for estimating the recombination fraction and to greater power for detecting linkage, compared to separate analyses. We concentrated on the quantitative phenotype Q2 and analyzed linkag

Comparison of variance components and si

Comparison of variance components and sibpair-based approaches to quantitative trait linkage analysis in unselected samples

✍ Jeff T. Williams; John Blangero 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 128 KB 👁 2 views

We compared the statistical performance of sibpair-based and variance components approaches to multipoint linkage analysis of a quantitative trait in unselected samples. As a benchmark dataset, we used the simulated family data from Genetic Analysis Workshop 10 [Goldin et al., 1997], and each method

A Minimum Distance Estimation Approach t

A Minimum Distance Estimation Approach to Estimate the Recombination Fraction from a Marker Locus in Robust Linkage Analysis for Quantitative Traits

✍ Andreas Ziegler; Christian Kastner 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 564 KB

The Maximum-Likelihood-Binomial method r

The Maximum-Likelihood-Binomial method revisited: a robust approach for model-free linkage analysis of quantitative traits in large sibships

✍ Aurelie Cobat; Laurent Abel; Alexandre Alcaïs 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 254 KB 👁 2 views

Model-free linkage analysis methods, based on identity-by-descent allele sharing, are commonly used for complex trait analysis. The Maximum-Likelihood-Binomial (MLB) approach, which is based on the hypothesis that parental alleles are binomially distributed among affected sibs, is particularly popul