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A broad-spectrum matrix metalloproteinase inhibitor prevents hemorrhagic complications induced by tissue plasminogen activator in mice

✍ Scribed by K. Mishiro; M. Ishiguro; Y. Suzuki; K. Tsuruma; M. Shimazawa; H. Hara


Book ID
116789573
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
854 KB
Volume
205
Category
Article
ISSN
0306-4522

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## Abstract Fibroblasts, a major constituent of gingival connective tissue, can produce immunoregulatory cytokines and proteolytic enzymes that may contribute to tissue destruction. In this study, we evaluated the production of matrix metalloproteinases (MMPs), tissue inhibitors of MMPs (TIMPs), an