A block to elongation is largely responsible for decreased transcription of c-myc in differentiated HL60 cells

A new molecular role for iron in regulat

A new molecular role for iron in regulation of cell cycling and differentiation of HL-60 human leukemia cells: Iron is required for transcription of p21(WAF1/CIP1) in cells induced by phorbol myristate acetate

✍ Y. Gazitt; S.V. Reddy; O. Alcantara; J. Yang; D.H. Boldt 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 467 KB 👁 2 views

To investigate the role of iron in hematopoiesis, we studied effects of iron deprivation on PMA-induced monocyte/macrophage differentiation in HL-60 cells. Iron deprivation induced by desferrioxamine (DF) blocked PMA-induced differentiation and induced S-phase arrest and apoptosis in up to 60% of ce