A block-diagrammatic approach to metabolic control analysis
β Scribed by Asok K. Sen
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 751 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0020-711X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The problems of engineering increased flux in metabolic pathways are analyzed in terms of the understanding provided by metabolic control analysis. Overexpression of a single enzyme is unlikely to be effective unless it is known to have a high flux control coefficient, which can be used as an approx
The formulation of the standard summation and connectivity relationships as a statement that the matrix of all the elasticities in a system is the inverse of the matrix of all the control coefficients is completely general, provided that only control coefficients for independent fluxes and concentra
Based on a simplified model of a linear metabolic pathway (Kacser & Burns, 1973), and on the principles of Metabolic Control Analysis, an equation useful for predicting the maximum flux through a system after removing inhibitory feedback interaction is presented. The analysis shows that only when th