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A Bivariate Whole Genome Linkage Study Identified Genomic Regions Influencing Both BMD and Bone Structure

✍ Scribed by Xiao-Gang Liu; Yong-Jun Liu; Jianfeng Liu; Yufang Pei; Dong-Hai Xiong; Hui Shen; Hong-Yi Deng; Christopher J Papasian; Betty M Drees; James J Hamilton; Robert R Recker; Hong-Wen Deng

Book ID: 111485614
Publisher: American Society for Bone and Mineral Research
Year: 2008
Tongue: English
Weight: 578 KB
Volume: 23
Category: Article
ISSN: 0884-0431
DOI: 10.1359/jbmr.080614

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## Abstract Bone size is an important determinant of osteoporotic fractures. For a sample of 53 pedigrees that contains more than 10,000 relative pairs informative for linkage analyses, we performed a whole‐genome linkage scan using 380 microsatellite markers to identify genomic regions that may co