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A Bivariate Frailty Model with a Cure Fraction for Modeling Familial Correlations in Diseases

โœ Scribed by Andreas Wienke; Paul Lichtenstein; Anatoli I. Yashin


Book ID
110725129
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
123 KB
Volume
59
Category
Article
ISSN
0006-341X

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We use frailty models to analyse the e!ect of latent genetic and environmental risk factors on hazard functions in nuclear families. The approach expresses latent risk factors (frailties) as functions of the e!ects of a single major gene and shared familial risk. The latter may result from shared po