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A bispecific single-chain antibody that mediates target cell-restricted, supra-agonistic CD28 stimulation and killing of lymphoma cells

✍ Scribed by Rammensee, H-G; Jung, G; Otz, T; Große-Hovest, L; Hofmann, M


Book ID
109886636
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
284 KB
Volume
23
Category
Article
ISSN
0887-6924

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## Abstract Endowing tumor cells with costimulatory signals for T cell activation has emerged as a promising strategy for tumor immunotherapy. Costimulatory molecules were either transfected into tumor cells to generate vaccines or were fused, __e.g.__ to antibodies against tumor‐associated antigen