A Biomimetic Potentiometric Sensor Using Molecularly Imprinted Polymer for the Cetirizine Assay in Tablets and Biological Fluids
✍ Scribed by Mehran Javanbakht; Solmaz Eynollahi Fard; Majid Abdouss; Ali Mohammadi; Mohammad Reza Ganjali; Parviz Norouzi; Leila Safaraliee
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 183 KB
- Volume
- 20
- Category
- Article
- ISSN
- 1040-0397
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✦ Synopsis
Abstract
Despite the increasing number of applications of molecularly imprinted polymers (MIPs) in analytical chemistry, the construction of a biomimetic potentiometric sensor remains still challenging. In this work, a biomimetic potentiometric sensor, based on a non‐covalent imprinted polymer was fabricated for the recognition and determination of cetirizine. The MIP was synthesized by precipitation polymerization, using cetirizine dihydrochloride as a template molecule, methacrylic acid (MAA) as a functional monomer and ethylene glycol dimethacrylate (EGDMA) as a cross linking agent. The sensor showed high selectivity and a sensitive response to the template in aqueous system. The MIP‐modified electrode exhibited Nernstian response (28.0±0.9 mV/decade) in a wide concentration range of 1.0×10^−6^ to 1.0×10^−2^ M with a lower detection limit of 7.0×10^−7^ M. The electrode has response time of ca. 20 s, high performance, high sensitivity, and good long term stability (more than 5 months). The method was satisfactory and used to the cetirizine assay in tablets and biological fluids.