✦ LIBER ✦
A biologically active 1,2,3-trithiane derivative from the New Zealand ascidain Aplidium sp. D.
✍ Scribed by Brent R. Copp; John W. Blunt; Murray H.G. Munro; Lewis K. Pannell
- Book ID
- 104232931
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 333 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
cis-5-Hydroxy-4-(4'-hydroxy-3'-methoxyphenyI)-4-(2"-imidazolyI)-1 ,2,3-trithiane 1 was isolated from the New Zealand ascidian Aplidium sp. D. In neutral or slightly basic solution 1 interconverts to the trans isomer 3. These isomers are the precursors to 2-vanilloyl imidarole 2, previously reported from an extract of an Australian species of Aplidium.
Both trithiane isomers are active against P388 leukemia cells in vitro.