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A biogenetic-type synthesis of (±)-aplysiadiol, a brominated diterpene isolated from the marine mollusc aplysia kurodai

✍ Scribed by Haruki Niwa; Shigeru Ieda; Hideaki Inagaki; Kiyoyuki Yamada


Publisher
Elsevier Science
Year
1990
Tongue
French
Weight
151 KB
Volume
31
Category
Article
ISSN
0040-4039

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✦ Synopsis


f)-Aplysiadiol (1). a brominated diterpene having a ram, prenylated eudesmane skeleton was synthesized starting with (*)-hedycaryol(2) in a biogenetic manner.

Aplysiadiol(1) isolated ftom the Japanese marine mollusc ApZysti kurodai is a brominated diterpene having a rate, prenylated eudesmane skeleton.1) A biogenesis of aplysiadiol( 1) is shown in Scheme I. A prenylated germacrene-like precursor (A) biO8yMhe8ized from geranylgeranyl pyrophosphate (GGPP) may be


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