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A biochemical measure of monoamine oxidase type A and B inhibitor effects in man

โœ Scribed by Iain C. Campbell; David J. Shiling; Steven Lipper; Stanley Slater; Dennis L. Murphy


Book ID
115996007
Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
543 KB
Volume
15
Category
Article
ISSN
0022-3956

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Biochemical and pharmacologic properties
โœ Helen L. White; Philip W. Scates; Jane C. Harrelson; Thomas E. Johnson; Ron M. N ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 149 KB ๐Ÿ‘ 1 views

## 2614W94 [3-(1-trifluoromethyl) ethoxyphenoxathiin 10,10-dioxide] is a selective, reversible inhibitor of monoamine oxidase-A with a competitive mechanism of inhibition and a K i value of 1.6 nM with serotonin as substrate. In pretreated rats, the ED 50 value after single oral dosing was 1.7 mg/