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A bifunctional hybrid molecule of the amino-terminal fragment of urokinase and domain II of bikunin efficiently inhibits tumor cell invasion and metastasis

✍ Scribed by Hiroshi Kobayashi; Dan Sugino; Ming Yu She; Hidekazu Ohi; Yasuyuki Hirashima; Hiromitsu Shinohara; Michio Fujie; Kiyoshi Shibata; Toshihiko Terao

Book ID: 114429127
Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 285 KB
Volume: 253
Category: Article
ISSN: 1432-1327
DOI: 10.1046/j.1432-1327.1998.2530817.x

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## Abstract A Kunitz‐type protease inhibitor, bikunin, is known to suppress the invasion and metastasis of cancer cells. HI8, a carboxyl‐terminal domain of bikunin, is an active site of this glycoprotein. To increase its affinity for cancer cells, we constructed a chimeric gene, __ATF‐HI8__, and in